Defeat the Bio-Bulkhead and help the Outbounders in Borderlands 4’s One Fell Swoop main mission with the help of this article.

Players will begin the One Fell Swoop, the fourth main mission in Borderlands 4, after finishing up the “A Lot to Process.” By this time, you will already be in Zadra’s lab, where the events of this quest start. There is a lot to do in it, such as speaking to Zadra, infiltrating Sol’s Production Facility, defeating the Bio-Bulkhead, and taking down an Outlander’s Airship. But do not worry, we will walk you through all of it step-by-step in this article.
Also, another thing to note is that many players have encountered a glitch while trying to interact with Zadra in this mission. We have also provided some potential fixes for that. Gearbox Software is also aware of this bug, so it might get fixed soon.
Borderlands 4: One Fell Swoop Walkthrough
One Fell Swoop is the fifth main mission in 2K’s Borderlands 4. As we previously mentioned, there is a lot of shooting and killing in it per tradition and a boss fight. For that, we recommend having the option to do some corrosive and cryo damage, as it will make your life easier during the mission. Other than that, there are also some minimal puzzles that you will need to solve, which won’t be too much of an issue.
Also Read: Borderlands 4: PC Optimization Guide: Best Settings for Optimal Performance
Part 1: Sabotage Sol’s Production Facility

After completing the previous mission, you will find yourself in Zadra’s lab at the start of One Fell Swoop. Talk to her to truly begin the journey. Now, some players have mentioned running into a glitch in this part, in which Zadra is stuck in an animation loop. A potential fix for it is to start a new save with a vault hunter, skip the prologue, then quit to the main menu, and at last, switch to your original hunter. However, this might not work for everyone.
Once you are past that, speak to Zadra and follow her to get out of the secret base. Then, you will have to reach Sol’s Production Facility, north of your current location, and within the Dissected Plateau of the Fadefields. After infiltrating it, you can run past the big enemies and take the door to your right, and you will find some Order production line guards. Kill all of them and go to the northwest of that room to find a console. Interact with it to open the golden barricade and then go deeper into the facility.
After walking for a bit, you will come across the Synth Processor Valve, open it, and destroy it. After that, return to Zadra at the main entrance. Then, wait for her to activate an elevator.
Part 2: Defeat the Bio-Bulkhead

Zadra will take you to a new area past a golden barrier. Kill every enemy you find there, and then you will come across an armored door. You won’t be able to open it with your hands or bullets. So save your energy and use the vent above it to enter the lab beyond. Clear the area of foes and then activate the locust containers south of the room. These will help you open white doors as well as against the upcoming boss.
Use your grappling hook to grab the containers and then throw it at the door to open it. After that, repeat the process for the next door, and proceed further. Soon, you will enter a boss arena just past some vending machines. Here, you will meet the Bio-Bulkhead. His armor is immune to your bullets. However, you can throw locust canisters at it to destroy it and compromise the creature. You will find plenty of said canisters on the sides of the room.
Once the armor is removed, you will notice his real health bar, which is yellow. It means that the Bio-Bulkhead is vulnerable to Corrosive and Cryo damage. If you have followed our steps so far, you should be completely prepared for this moment. Kill the creature in true Borderlands fashion and then move forward.
Read More: All Side Missions in Borderlands 4
Part 3: Help the Outbounders and Destroy the Airship

Once the Bio-Bulkhead fight is over, follow the quest marker and use the various grappling spots to reach the Airship. However, it will fly off the moment you get there. This is by design, so do not worry, and simply go back to the Outbounder’s HQ by a vehicle or fast travelling to the nearest point. There, you will find them under attack.
Go straight to Rush following the marker and revive him first. After that, help him out and kill all the enemies in the area. Then, your objective will be to reach the Fast Travel Station. Keep moving towards the next objective marker, and then remove the debris with your grappling hook. After that, go back to the southeast area of the launchpad at the surface. Take the orange portal to enter the airship.
Inside, you will find a red circular button that will expose three critical points of the ship. Shoot and destroy all three spots and then jump down to land. This will mark the end of the One Fell Swoop mission in Borderlands 4 and pave the way for Rush The Gate.

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