Here is a complete guide on how to unlock all Mutations in Grounded 2, along with details about their unique effects.

Mutations are one of the returning mechanics in Grounded 2. The fan favorite system allows players to customize their build with unique passive perks. The Grounded 2 early access currently offers 18 available Mutations under four broad categories, while most make comebacks from the original Grounded. Completing specific tasks associated with the perks unlocks the Mutations.
Once unlocked, players can activate multiple Mutations to strengthen their builds. You start with 2 active Mutation slots, but this limit can be increased using Milk Molars. Completing the advanced tier challenges unlocks additional perks for the specific Mutations, enhancing their effects. This guide provides a complete overview of all the Mutations in Grounded 2 and how to unlock them.
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All Grounded 2 Mutations and How To Unlock Them

Here is a complete list of all available Mutations in Grounded 2 and how to unlock them:
Fighting Styles
Mutation | Effect | Challenges |
---|---|---|
Lil Fist | Lil Fist: Add stack towards charged attacks for first attacks. Charged attacks use all stacks and deliver a devastating blow. Fist Master: Fist attacks generate two stacks while dealing bonus stun. | Kill 40/100/200 creatures with fists |
Smasher | Smasher: Club attacks inflict more stun. Club Master: Stunned enemies take more damage from Club attacks. | Kill 40/100/200 creatures with clubs |
Javelineer | Javelineer: Throwing spears deals more damage. Spear Master: Charged spear attacks deal increased damage. | Kill 40/100/200 creatures with spears |
Assassin | Assassin: Critical hit chance increases for Dash strokes. The critical hit damage increases for Dual daggers and sickles. Dagger Master: Increases the critical hit chance temporarily for every dagger and sickle kill. | Kill 40/100/200 creatures with daggers |
Sharpshooter | Sharpshooter: Critical hit chance increases for fully charged bow shots. Bow Master: Deal additional damage with the perfectly charged bow shots. | Kill 40/100/200 creatures with bows |
Blademaster | Blademaster: Reduces enemy attack damage temporarily when hitting enemies with the sword. Sword Master: Temporarily removes the stamina timer when hitting enemies with the sword. | Kill 40/100/200 creatures with swords |
Whittle Wizard | Whittle Wizard: Enhances the elemental effects of Staff attacks. Staff Master: Increases the critical chance of staff attacks for frozen and burning enemies with max buildup | Kill 40/100/200 creatures with staves |
Combat Abilities
Mutation | Effect | Challenges |
---|---|---|
Parry Master | Parry Master: Restore stamina for perfect blocks | Perform 30/80/150 perfect blocks |
Ambush | Ambush: Deal critical hits for stealth attacks. Cloak and Dagger: Increases the critical hit damage for ambush attacks with daggers. | Land 30/80/150 ambush attacks |
Frenzy | Frenzy: Rage builds up on melee attacks. While enraged, you deal increased damage and regenerate health. | Defeat the mysterious stranger |
Guard Dog | Defender: Attack Up: Enemies attacking your base take more damage. | Complete 1/4/9 MIX.R events |
Exploration
Mutation | Effect | Challenges |
---|---|---|
Natural Explorer | The Quickness: Allows you to run faster when outside of combat. | Discover 20/50/80 points of interest |
Trapper Peep.R | Yoked Blows: Critical hit damage multiplier increases. | Collect 25/50/75 gold cards |
Survival
Mutation | Effect | Challenges |
---|---|---|
Cardio Fan | Hyperstamina: Increases stamina regeneration rate. Exhaustion: reduces the exhaustion phase. | Deplete stamina 100/250/500 times |
Reliable Friend | Revive Speed: Increases the reviving speed. | Revive 5/15/30 allies |
Fresh Defense | Sizzle Reduction: Reduces the Sizzle damage. Burn Resistance: Reduces the burn damage. Gas Resistance: Reduces the poison damage. | Eat 1/5/10 mint shards |
Spicy Safety | Chill Reduction: Reduces the chill rate. Freeze Resistance: Reduces the frozen damage. Shatter Resistance: Reduces the shatter damage while frozen. | Eat 1/5/10 spicy shards |
Mithridatism | Venom Reduction: Reduces the rate of venom buildup. Venom Resistance: reduces the damage from venom. | Kill 5/50/150 venomous creatures |

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