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Painkiller: Best Settings for 1440p

By / Tech / October 25, 2025

These are the best settings for playing Painkiller at 1440p resolution on GPUs with up to 12GB VRAM.

Painkiller (Image via 3D Realms)
Painkiller (Image via 3D Realms)

Painkiller plays exceptionally well at 1440p. The game is incredibly high-paced, and you can team up with up to four people to slay enemies, earn rewards, and complete quests. The game runs well on modern hardware but has a few performance issues. Firstly, it’s incredibly CPU-intensive, and secondly, the rendered output image appears soft, with artifacts and shimmering.

The settings below address these issues and ensure a great gameplay experience.

Read More: Painkiller: Best Settings for RTX 50 Series

Painkiller – Best Settings To Play at 1440p

Painkilller Graphics Settings page 3 (Image via 3D Realms)
Painkiller Graphics Settings page 1 (Image via 3D Realms)

As we mentioned, image softness and CPU-bound issues are the most significant problems in the game. To counter both of these, we are using Intel XeSS 2.0 upscaler for anti-aliasing. XeSS 2.0 is an AI-based algorithm that is very GPU-intensive.

This approach allows us to shift the compute load more toward the GPU and offload CPU resources. XeSS 2.0 will clean up the image, reduce softness and shimmer, improve temporal stability, and enhance clarity. As for the CPU-bound nature, shifting the load to the GPU resolves it. 

We recommend a GPU with power comparable to an RTX 4060 Ti to play this game with our settings at 1440p. Anything lower would work, but the frame rate won’t be 100+. That said, you can customize these settings to your liking and adjust each option individually.

Best Settings Explored

SettingValue
Screen Resolution2560 x 1440 (16:9)
Resolution Scale100
Screen ModeBorderless
Intel® XeSS Super Resolution 2.0Native Anti-Aliasing
Sharpness1.5
VSyncOff
Frame Rate LimitUnlimited
FOV (Field of View)90
Gamma—
Motion BlurOff
Graphics QualityCustom
View DistanceFar
Anti-AliasingGrayed Out
Post-ProcessingHigh
Shadows QualityHigh
Texture QualityHigh
Effects QualityHigh
Foliage QualityHigh
Shading QualityHigh
Animation QualityHigh

Read More: Painkiller: Best Settings for RTX 30 Series

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