Understanding Vitality Damage is essential in Titan Quest 2 to develop a build around the special stat and enhance your combat.

Titan Quest 2 throws players into a perilous world teeming with mythological creatures, set in a Greek mythology-inspired setting. On your mission to end the reign of Nemesis, the Goddess of Retribution, you will often be swarmed by large groups of enemies. While raw strength and power can help you dominate the battlefield, they are not enough on their own.
In addition to strength, you need to understand the nuances, such as Glancing Hit and various damage types, to master the art of combat. Vitality Damage is one of the special damage types that deals damage directly to the enemy’s vitality. Learn what Vitality Damage is and how it works in Titan Quest 2.
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What Is Vitality Damage in Titan Quest 2?

Vitality Damage, or Life Damage, is a special type of damage that directly affects the enemy’s HP. It targets the enemy’s vitality directly and reduces their health, making it a powerful offensive strategy. For instance, you inflict Vitality Damage per stack when the Doom effect ends. You can apply Vitality Damage to enemies through specific skills that mention it in their effects. This includes Mark for Death, Dismantling Tactics, and Taste for Blood. Here is how it works:
- Mark for Death: Hitting a marked enemy deals an extra 10% of the hit as Vitality Damage.
- Dismantling Tactics: Killing an enemy allows you to deal 5 Vitality Damage to your Mark.
- Taste for Blood: Increases the Vitality Damage by 10% along with 12% increased Lifesteal.
The only way to mitigate Vitality Damage is through the Vitality Resistance stat, which offers resistance to this special damage type.
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