Boss fights are the most fun part of any game. So In this list, we will rank the top 5 strongest Marvel’s Spider-Man 2 bosses.

Boss fights are a crucial aspect of any game, especially superhero games. Going against the many antagonists with their unique move set and multiple phases of battle, is something all players look forward to.
Insomniac Games teased a few of their game’s bosses earlier in the trailers, such as Venom, Kraven, and Lizard. But fans were eager to see which other Spider-Man villains were in the game. The developers did not disappoint in that regard; Spider-Man 2 has many boss fights, and all of them are great. However, some of them are more memorable than the others. In this article, we will discuss the strongest bosses in Marvel’s Spider-Man 2 who will test your skills and patience, such as Scream, Kraven, Venom, and more.
Top 5 Strongest Bosses in Spider-Man 2
We all knew that big names from Spider-Man’s rogues gallery would be in Spider-Man 2. But Insomniac Games went a little bit further. The game is full of both popular and lesser-known Spider-Man villains you can fight. Each of the bosses has their unique storylines and move-sets.
From delivering on teases from the previous game, such as Yuri Watanabe as Wraith, to completely new villains like Scream, Marvel’s Spider-Man 2 has it all. Even with the new abilities and gadgets Peter and Miles have in the game, the players are going to be challenged and tested in every boss fight they encounter. Some of these fights are harder than the rest, and in this list, we will rank the top 5 hardest bosses in Spider-Man 2.
5. Wraith

Yuri Watanabe was once a police officer with a strong moral code and Peter’s friend. However, during The City That Never Sleeps DLC in Marvel’s Spider-Man, we saw Yuri getting increasingly violent and her moral code getting convoluted as the story progressed.
In the end, Yuri left her job as a police officer and disappeared. But she did not stay in the shadows for long. Yuri Watanabe finally appeared as the vigilante known as Wraith in Marvel’s Spider-Man 2, and Peter now has to fight his former friend and bring her back from a path of violence and vengeance.
Wraith is a tricky boss, to say the least. She is fast and can attack from both close and long-range; she also has a lot of tricks up her sleeve. Wraith can dodge and parry Peter’s attacks with ease, so your gadgets and the symbiote abilities will be immensely helpful in the fight against her. She will try to close the distance with a slide to attack Peter, so stay alert and try to avoid these attacks.
Wraith can also lunge forward quickly or throw her scythe from a distance. And when you have dealt enough damage, she will throw smoke bombs to blur your vision and attack you. Players must rely on their reflexes and Peter’s Spider-Sense to avoid damage in this scenario. We recommend every player reach the “I Knew You Had It In You” mission in The Flame questline to fight her.
4. The Lizard

Doctor Curt Connors is a name every Spider-Man fan is familiar with. The good-willed scientist became the notorious monster named The Lizard when a science experiment went wrong on his quest to help all of humanity. His inhuman form, aggressive nature, and enormous size make him one of the strongest bosses in the game. Additionally, the Lizard brings a physical challenge to Spider-Man while the man underneath the monster triggers a moral and emotional dilemma for Peter.
Lizard is a very agile boss, and he won’t give the players any chance to breathe. The moment the fight begins, he will come out at Peter with quick slash attacks with his claws. Additionally, he will use his jaws for crush attacks; these attacks cannot be blocked or parried, so dodging them is the only option.
The Lizard can also climb and run up walls. When he does that, he will either lunge at Peter or throw debris at him. And his tail sweep is something players will have to deal with as well. The black suit’s symbiote abilities will be essential in inflicting heavy damage while the web shooters will play a crucial part in creating opportunities to hit Lizard. Players can also use some sections of the floor and walls to stun the enemy.
3. Kraven: The Hunter

It is evident that Insomniac took inspiration from the Last Hunt storyline from the comics for Spider-Man 2. Both in that story and in the game, Kraven is a formidable opponent. In Marvel’s Spider-Man 2, Kraven abducts Miles in order to force Peter to fight him. Another thing to note is that at this point in the game’s story, the symbiote has corrupted Peter’s mind and he is more aggressive and merciless. However, Kraven is a hunter, and a hunter always has more than one way to defeat his prey.
Players will have to stay patient and strategize because Kraven is not an easy target to fight. His ground slam cannot be parried or blocked, so Peter will have to resort to dodging. Additionally, Kraven can also parry attacks.
He has many weapons he can use, including a double-handed axe, a sniper rifle, flashbangs, and ground mines. However, he won’t stop there. The hunter will use robot hounds as distractions and a giant bell in the second phase of the fight to stun the symbiote while he goes invisible and tries to attack Peter. The Black Suit will provide many abilities to fight Kraven, but we also recommend using gadgets like the web grabber.
2. Peter With the Symbiote Suit

Spider-Man 2 offers gamers something new with this boss battle. Players have fought many Spider-Man villains in the previous two installments. However, this time fans will get to fight Peter Parker himself.
After almost killing Kraven under the corruption of the symbiote, Peter is confronted by Miles about his growing violent behavior, which leads to a fight between the two Spider-Men. The fight has multiple phases and has one of the most iconic scenes in the game as Peter finally gets rid of the symbiote.
What makes Peter one of the strongest bosses in the game is the fact that he is Spider-Man. He is just as fast as he is strong, and his webs and abilities provide an extra challenge that players must overcome. His quick and fluid movements make him a difficult target to hit, and it also makes his attacks hard to dodge, so players must develop their parrying skills for this fight.
Additionally, the game throws the symbiote abilities the players have been using to this point against them, which adds another layer of complexity. In this fight, the bell in the arena can be used to stun Peter, and Miles’s abilities can be quite effective.
1. Venom

Insomniac announced Venom as the main antagonist of Marvel’s Spider-Man 2 in the official reveal trailer, so the symbiote being the strongest boss in the game is not a surprise. He is an iconic and integral part of the Spider-Man mythos and a driving force in the story of the game.
Gamers will get to fight Venom during the last act of the game. The fight will have four phases, and players will be able to fight the final boss with both Peter and Miles. We have ranked Venom as the strongest boss in the game due to the versatility of his attacks, his ferocious approach, and his ability to manipulate the fight in every phase.
Venom’s speed and the variety of his attacks can be really hard to deal with. He will come at the players with everything he’s got from the beginning; his ground slams, tentacle attacks, grab attacks, and AoE attacks won’t give the players any chance to feel at ease. Additionally, Venom will manipulate the arena and force the players to move into a different one; he will also spawn minions and gain a barrier on his health, which will make the fight even more difficult.
In the third phase, Venom will grow giant wings, which will give him the ability to throw projectiles and attack from mid-air. We recommend using Peter’s anti-venom abilities and Miles’s electricity-focused venom abilities frequently. Overall, it is a great final fight that will test the player’s grasp of the game’s mechanics.
Conclusion
Our list of the top 5 strongest Marvel’s Spider-Man 2 bosses concludes here. The game is launching on January 30, 2025, for PC, and it has many more boss fights and objectives for the players. You can also check out our Spider-Man 2 boss guides if you want to know how to beat any of the bosses we mentioned in this article.
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