Borderlands 4: Bio Bulkhead Boss Guide

The boss guide will cover how to find and defeat Bio Bulkhead within Borderlands 4 including what Legendary items you can get from this.

Bio Bulkhead Boss in Borderlands 4 (Image via 2K)
Bio Bulkhead Boss in Borderlands 4 (Image via 2K)

There is no shortage of bosses for you challenge in Borderlands 4. Dozens of unique bosses, each with their own special mechanics and challenges. Many of these bosses are optional, and you can face them when you wish. But some of these bosses are part of the main story, and cannot be avoided.

One such main story boss is the Bio-Bulkhead. Here is a complete guide on the Bio-Bulkhead in Borderlands 4.

Borderland 4: Bio-Bulkhead Boss Location

Bio Bulkhead Boss location (Image via 2K | @ZaFrostPet/YouTube)
Bio Bulkhead Boss location (Image via 2K | @ZaFrostPet/YouTube)

As stated above, the Bio-Bulkhead is a main story boss and must be beaten to progress in the story. This boss is encountered during the One Fell Swoop main mission, which is the fifth main mission in the game. It is found in the Synthetic Nave facility in the Dissected Plateau region.

How To Beat Bio-Bulkhead Boss in Borderlands 4

Here are some tips to help with this boss fight:

  • The Bio-Bulkhead has a unique mechanic that prevents you from simply unloading on it until it drops dead. That mechanic is its super armor, which makes it immune to all damage.
  • There is a way to remove this armor and level the playing field. The boss arena has numerous locust canisters placed around it. Picking one of these up and throwing it at the Bio-Bulkhead will temporarily disable its armor, allowing you to let loose.
  • The Bio-Bulkhead is weak to Corrosive and Cryo damage, so it is recommended to use these types of weapons. The boss is resistant to Shock, Incendiary, and Radiation damage, so try to avoid using them.
  • After a while, the boss’s super armor will return, and it will be invincible again. You will then have to throw another canister at the boss and repeat the process. Continue this until you eventually win.  
  • The boss is constantly moving and leaping towards you, so keep moving away from the creature at all times.

Bio-Bulkhead Legendary Drops and Rewards

There are three Legendary items you can obtain from the Bio-Bulkhead. These include the Legendary Pistol Budget Deity, as well as the Legendary Grenades Waterfall and Sho Kunai.

ItemTypeEffect
Budget DeityPistolD.O.P.E. Buoys – Throws 2 Combo Orbs, which place Atlas Target Lock on enemies damaged by Combo Orbs.
WaterfallGrenade OrdnanceWaterfall – Causes additional explosions when damaging targets.
Sho KunaiGrenade OrdnanceNinja Speed – Grants +10% Movement Speed for a short time with each consecutive hit, for a maximum of 7 stacks.

If you do not get the drops you are looking for, you can always rematch the boss with Moxxi’s Big Encore Machine. That will end the boss guide for Bio Bulkhead in Borderlands 4.


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