The First Descendant: Best Ultimate Python Build Guide

Discover how to get the Ultimate Python, the best modules, best stats, and more in our weapon build guide for The First Descendant!

Best Ultimate Python Build Guide in The First Descendant

The Python is an Ultimate weapon in The First Descendant, with a strong focus on Weak Point damage and a unique ability that can decrease an enemy’s DEF and Toxic Resistance. It’s best equipped by a poison Descendant such a Freyna, but other characters can take advantage of the drop in enemy defense, as well. However, this is primarily a single target, Colossus focused weapon, because the unique ability will only trigger on Weak Points.

All Python features in The First Descendant:

• Weapon Type: Submachine Gun
• Special Ability: Python Instinct
  • On hitting an enemy’s Weak Point, inflicts the unique ability Prey on target enemy. The Prey status lowers DEF and Toxic Resistance by 10% each.
• Pros: Lowers both enemy Defense and Toxis Resistance, a very strong weapon against Colossi
• Cons: Unique ability only triggers on hitting Weak Points, won’t be as useful against groups of enemies
• Best Characters: Freyna, Ajax
• Best Mods: Rifling Reinforcement, Action and Reaction, and Mental Focus

Python Advanced Stats

Below are the base advanced stats for the Python at level 1:

• Firearm ATK – 21
• Fire Rate – 923
• Rounds per mag – 30
• Reload time – 1.5 seconds
• Crit rate – 5%
• Crit damage – 1.3x
• Status chance – 3.45%
• Weakpoint damage – 2x

How to Get Ultimate Python in The First Descendant

The Ultimate Python will require you to reach Mastery Rank Level 1 before you can craft it with Magister Anais in Albion. Additionally, once you collect all of the needed materials, you will have to pay a 100,000 credit/gold fee. Finally, it will take 4 hours of research time for the Python firearm to be completed.

To Craft Ultimate Python you will need the following materials:

• 1 Python Polymer Synctium
  • Intercept Battle, Devourer (Normal), with Amorphous Material Pattern: 029
  • Farm Amorphous Material Pattern: 029 at Agna Desert zone, The Asylum operation dungeon
• 1 Python Synthetic Fiber
  • Intercept Battle, Gravewalker (Normal), with Amorphous Material Pattern: 005
  • Farm Amorphous Material Pattern: 005 at Kingston zone, Defend Albion Resource special operation
• 1 Python Nano Tube
  • Intercept Battle, Pyromaniac (Normal), with Amorphous Material Pattern: 039
  • Farm Amorphous Material Pattern: 039 at White-night Gulch zone, Block Kuiper Mining special operation
• 1 Python Blueprint
  • Intercept Battle, Dead Bride (Normal), with Amorphous Material Pattern: 025
  • Farm Amorphous Material Pattern: 025 at Echo Swamp zone, Defend Albion Resource special operation

Finding all of the materials for Python will require lots of different farming because the four items themselves do not drop from missions like some other ultimate materials do. Instead, you will need to first collect specific Amorphous Materials Patterns and you then use at the end of Colossi fights for a chance at the crafting piece you need. Therefore, this will take more time gather all the needed materials.

The methods we have listed above are the best grinds for each piece. However, if you wish to see all of the available options check out the Acquisition Info for The Python from the Journal/Social menu.

Best Modules for Ultimate Python in The First Descendant

Rifling Reinforcement, Action and Reaction, and Mental Focus are the best weapon mods for Python. Rifling Reinforcement and Action and Reaction modules both give a great bonus to overall Firearm attack. They should be standard go-to modules on all of your firearms, with few exceptions. With Mental Focus you take a hit to your Fire Rate, but this weapon fires pretty fast to begin with. Additionally, the Fire Rate UP module will offset the majority of this decrease.

Best Beginner Mods for Python

Below are the best beginner weapons mods for the Python:

• Have Aiming – Weak Point Damage +10%, Accuracy -5%
• Action and Reaction – Firearm ATK +15%, Recoil +5%
• Rifling Reinforcement – Explosive ATK +12%
• Weak Point Sight – Weak Point Damage +9%

Slot	Module
1 (First Row)	(empty)
2	Have Aiming
3	Action and Reaction
4	(empty)
5	(empty)
6 (Second Row)	(empty)
7	Rifiling Reinforcement
8	Weak Point Sight
9	(empty)
10	(empty)

Best Advanced Mods for Python

Below are the best advanced weapons mods for the Smithereens:

• Poison Priority – Toxic ATK +13%, Reload Time Modifier -8%
• Fixed Shot – Recoil -8%, Weak Point Damage +2%
• Mental Focus – Fire Rate -10%. When firing a firearm, Firearm ATK +0.25% for 2s
• Weak Point Aiming – Accuracy +8%, Weak Point Damage +2%
• Weak Point Sight – Weak Point Damage +9%
• Action and Reaction – Firearm ATK +15%, Recoil +5%
• Fire Rate UP – Fire Rate +6%
• Toxic Enhancement – Adds Toxic ATK equal to 8% of Firearm ATK
• Rifling Reinforcement – Explosive ATK +12%
• Have Aiming – Weak Point Damage +10%, Accuracy -5%

Slot	Module
1 (First Row)	Poison Priority
2	Fixed Shot
3	Mental Focus
4	Weak Point Aiming
5	Weak Point Sight
6 (Second Row)	Action and Reaction
7	Fire Rate UP
8	Toxic Enhancement
9	Rifling Reinforcement
10	Have Aiming

When upgrading weapon mods, be aware there is an increased cost and a max module capacity of 80. The material needed is Energy Activators, and you will get one of these after playing through the end of the campaign, or you can craft them with Anais. Therefore, you want to balance increasing mods and not attempt to max out every one. A balanced approach to firearm ATK, critical chance, and critical damage is the best (+3 or so to each).

Best Weapon Stats for Ultimate Python in The First Descendant

In the First Descendant weapon stats are randomly generated for all weapons when they drop or are created via crafting. You can change (or re-roll) them through the Weapon Readjustment system, which is covered in more detail below.

Here are the best weapon stats for Ultimate Python in The First Descendant:

• Firearm ATK
• Weak Point Damage
• Toxic ATK
• Bonus Firearm ATK (vs. Colossus)

In the First Descendant, weapon stats are randomly generated for all weapons when they are picked up as loot or picked up after crafting. You can change (or re-roll) them through the Weapon Readjustment system. Each weapon has four random traits or stats that can be rerolled to find the ideal trait. These regenerated traits are also random and so is their quality. Therefore, expect to spend a lot of materials to min-max the perfect roll.

How to Upgrade Ultimate Python

The First Descendant provides several different avenues for upgrading and improving your weapons by using their repair station Workbench. The Workbench is located in the same general area as Anais and weapons seller Deslin on the west side of Albion.

Weapon Transmission

Each time you craft an Ultimate weapon in The First Descendant, after collecting it from Anais you will find that it is a low Level 1 firearm. However, you can easily bring it up to your current weapon level by using the Weapon Transmission mechanic at the Workbench.

Finally, you will need to reach Mastery Rank 3.

To level up Python in The First Descendant you will need:

• Precision Phase Exchanger
  • 250 Liquid Metal
  • 50,000 credits/gold
  • 10:00 of research time

To get Superalloy and Liquid Metal in the First Descendant you will need to dismantle many weapons you don’t want by junking them. This breaks down the weapon into crafting materials you can use to make other items. Consequently, we highly recommend breaking down all of your excess weapons instead of selling them. Credits are easier to earn just by playing the game and completing missions.

Weapon Readjustment

In The First Descendant, the Weapon Readjustment mechanic allows you to use the Workbench to re-roll your weapon stats. Moreover, you can re-roll all of your stats at once, or lock individual stats you like and only re-roll the ones you want to change.

Finally, you will need to reach Master Rank 4 in order to unlock Weapon Readjustment at the Workbench.

To change Python stats in The First Descendant you will need:

• Fine Adjustment Control Axis x2
  • 200 Liquid Metal
  • 30,000 credits/gold
  • 1:00:00 of research time

Enhance Unique Ability

Each Ultimate weapon in The First Descendant comes with a unique ability that gives it a powerful effect and you can enhance the power of these abilities. This is another mechanic that you will use at the repair station Workbench, and it unlocks at Mastery Rank ???

However, unlike Weapon Transmission and Weapon Readjustment there is no unique crafting material you will need to create and use. To enhance the unique ability of Python, you will have to craft a duplicate. Then, take that Level 1 duplicate to the Workbench and sacrifice it to upgrade the Python ability to a stronger version.

How To Use Ultimate Python

The Python is a great weapon for any build because it debuffs DEF and Toxic resistance. Ideally, Freyna or Ajax can use this weapon as a replacement for Thunder Cage to debuff enemies in order for themselves or anyone else to do increased damage.

The Prey unique ability is triggered when you hit an enemy’s Weak Point, and inflicts the Prey condition on your target enemy. Moreover, the Prey status lowers DEF and Toxic Resistance by 10%. Combined with Freyna’s poison abilities which already boost her damage, this weapon can be absolutely lethal in her hands.

Furthermore, given that Python Instinct only procs when firing on Weak Points, it means that this weapon will only do it’s best DPS when you are fighting Colossi. While it’s base DPS will still be effective against waves of Vulgus enemies, you won’t be able to trigger the Prey effect and lower their defenses.

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